Unlocking Men’s Vitality: Understanding Testosterone Replacement Therapy and Enclomiphene

By Jerry and Lisa Meloche, Pharm.D., Owners, Compounding Pharmacists

Men’s health and testicular health, in particular, are often overlooked and under-discussed. June marks Men’s Health Month and a pivotal moment to shed light on the importance of testosterone replacement therapy (TRT) and the emerging role of enclomiphene. As we explore hormonal balance for men, Creative Scripts Pharmacy highlights the benefits and nuances of these treatments, guided by medical evidence and clinical insights.

Understanding Testosterone Replacement Therapy (TRT)
Testosterone, often dubbed the “male hormone,” plays a multifaceted role in men’s health, influencing vitality, muscle mass, bone density, libido, and mood. However, testosterone levels naturally decline with age, contributing to a myriad of symptoms such as fatigue, decreased libido, erectile dysfunction, and diminished cognitive function.1

TRT serves as a cornerstone in managing hypogonadism (testicular shrinkage), a condition characterized by low testosterone levels. According to recent studies, approximately 38% of men aged 45 and older experience testosterone deficiency.2 Factors such as aging, obesity, chronic illness, and certain medications can precipitate hypogonadism.3

The benefits of TRT extend beyond symptom alleviation. Research indicates that TRT may enhance muscle mass, bone density, cognitive function, and overall quality of life in hypogonadal men.4 Moreover, TRT has shown promise in mitigating the risk of cardiovascular disease and metabolic syndrome.5

Introducing Enclomiphene: A Holistic Approach
Enclomiphene, an estrogen receptor modulator, emerges as a promising adjunct to TRT, particularly in cases of secondary hypogonadism. Secondary hypogonadism arises from dysfunction in the hypothalamic-pituitary-gonadal axis, leading to inadequate testosterone production despite normal gonadal function.6

Enclomiphene stimulates the release of gonadotropins, namely luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby enhancing endogenous testosterone production.7 This mechanism offers a more physiological approach to restoring testosterone levels, circumventing the potential drawbacks of exogenous testosterone administration, such as testicular atrophy and infertility.8

Indications for Enclomiphene
Enclomiphene presents a viable option for men seeking fertility preservation or those desiring a more natural testosterone restoration process. Individuals with primary hypogonadism, characterized by testicular dysfunction, may benefit from enclomiphene therapy to augment endogenous testosterone secretion.9

Enclomiphene can optimize therapeutic outcomes, minimize adverse effects, and preserve fertility potential when used in conjunction with TRT, and is only available from compounding pharmacies. This synergy underscores the importance of personalized medicine and tailored treatment regimens offered at Creative Scripts Compounding Pharmacy.

The journey to empower men with vitality and well-being, integrating TRT and enclomiphene heralds a new era in men’s health management. Through evidence-based practices and innovative solutions, Creative Scripts Compounding Pharmacy remains steadfast in its commitment to enhancing the lives of men through bespoke pharmaceutical interventions.

Come in to see us or call AND MENTION THIS AD for a one-time $15 off a new or transferred prescription!

Creative Scripts Compounding Pharmacy

239-261-0050
600 Goodlette Road North #108
Naples, FL 34102
www.creativescripts.net

 

References:
1. Traish AM. Testosterone and weight loss: the evidence. Curr Opin Endocrinol
Diabetes Obes. 2014;21(5):313-322.
2. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects
of aging on serum total and free testosterone levels in healthy men. Baltimore
Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86(2):724-731.
3. Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with
hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol
Metab. 2018;103(5):1715-1744.
4. Fui MNT, Dupuis P, Grossmann M. Lowered testosterone in male obesity:
mechanisms, morbidity and management. Asian J Androl. 2014;16(2):223-231.
5. Corona G, Maseroli E, Rastrelli G, et al. Cardiovascular risk associated with
testosterone-boosting medications: a systematic review and meta-analysis.
Expert Opin Drug Saf. 2014;13(10):1327-1351.
6. Kumar N, Crocker BD, Smith RG. Testosterone suppression of the HPT axis.
J Androl. 2008;29(6):622-627.
7. Food and Drug Administration. Androxal (enclomiphene) tablets, for oral use:
Highlights of prescribing information. Accessed April 30, 2024.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021763s000lbl.pdf
8. Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate stimulates the
endogenous production of testosterone and sperm counts in men with low
testosterone: comparison with testosterone gel. J Sex Med. 2014;11(1):199-207.
9. Hsieh TC, Pastuszak AW, Hwang K, Lipshultz LI. Concomitant intramuscular
human chorionic gonadotropin preserves spermatogenesis in men undergoing
testosterone replacement therapy. J Urol. 2013;189(2):647-650